Diabetes & Metabolism Journal

Original Articles

Genetics
Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran: Mohammad Pourahmadi, Saiedeh Erfanian, Malihe Moradzadeh, Abdolreza Sotoodeh Jahromi; Diabetes Metab J. 2015;39(6):512-517. Published online November 13, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.6.512

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Background

Transcription factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt signaling pathway. High levels of TCF7L2 have been reported in most human tissues, including the heart, lung, brain, liver, kidney, placenta, adipose tissues, and pancreatic β-cells. The purpose of this study was to assess the association between TCF7L2 polymorphisms (rs12255372 and rs7903146) and type 2 diabetes mellitus in the city of Jahrom, Iran.

Methods

This case-control study was conducted with 200 patients referred to Diabetes Clinics and 200 healthy subjects in Jahrom City. Biochemical characteristics were first determined. TCF7L2 rs1255372 and rs7903146 polymorphisms were then genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

T-allele frequencies of both single nucleotide polymorphisms (SNPs) were significantly higher in diabetic patients than in normal glucose-tolerant subjects (rs12255372: 20.3% vs. 14.5%; rs7903146: 28.5% vs. 22.25%). The rs12255372 (G/T) polymorphism analysis showed an odds ratio of 0.473 (95% confidence interval [CI], 0.170 to 1.314; P=0.151) for the TT genotype and 0.646 (95% CI, 0.410 to 1.019; P=0.060) for the TG genotype, compared with the GG genotype. The rs7903146 (C/T) polymorphism odds ratios for TT and TC genotypes were 0.564 (95% CI, 0.280 to 1.135; P=0.109) and 0.751 (95% CI, 0.487 to 1.157; P=0.194) compared with the CC genotype, respectively.

Conclusion

The rs12255372 and rs7903146 SNPs of the TCF7L2 gene were not associated with insulin resistance in the evaluated population.

Citations

Citations to this article as recorded by

Association between Transcription Factor 7-Like 2 Gene Polymorphisms rs7903146 and rs12255372 with the Risk of Diabetic Nephropathy among South Indian Population
Balaji Ramanathan, Kumaravel Velayutham
Chronicle of Diabetes Research and Practice.2024; 3(1): 8. CrossRef
Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population
Asma Salauddin, Kallyan Chakma, Md. Mahbub Hasan, Farhana Akter, Nowshad Asgar Chowdhury, Sumon Rahman Chowdhury, Adnan Mannan
Molecular Biology Reports.2023; 50(1): 609. CrossRef
Role of rs7903146 polymorphism and adropin serum level in patients with diabetes mellitus; a case–control study from Isfahan, Iran
Abbas-Ali Palizban, Abdol-Hamid Yazdani, Hamidreza Jahanbani-Ardakani
Archives of Physiology and Biochemistry.2022; 128(2): 378. CrossRef
PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus
Hadeel Ahmed Shawki, Ekbal M. Abo-hashem, Magdy M. Youssef, Maha Shahin, Rasha Elzehery
Journal of Diabetes & Metabolic Disorders.2022; 21(1): 241. CrossRef
Case-control study on the association between the GATA2 gene and premature myocardial infarction in the Iranian population
Peyman Izadpanah, Ehsan Khabbzi, Saiedeh Erfanian, Simin Jafaripour, Mohammad Shojaie
Herz.2021; 46(1): 71. CrossRef
Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population
Valeriy V. Benberin, Tamara A. Vochshenkova, Gulshara Zh. Abildinova, Anna V. Borovikova, Almagul A. Nagimtayeva
Journal of Diabetes & Metabolic Disorders.2021; 20(1): 131. CrossRef
The role of transcription factor 7‐like 2 in metabolic disorders
Zhensheng Zhang, Li Xu, Xiao Xu
Obesity Reviews.2021;[Epub] CrossRef
Association of transcription factor 7-like 2 (rs7903146) gene polymorphism with diabetic retinopathy
Hadeel Ahmed Shawki, Ekbal M.Abo-Hashem, Magdy M. Youssef, Maha Shahin, Rasha Elzehery
Ophthalmic Genetics.2020; 41(5): 420. CrossRef
Association of SLC30A8, CDKAL1, TCF7L2 and HHEX Gene Polymorphisms with Type 2 Diabetes in the Population of North East India
A. Bhowmick, P. Sarkar, M. P. Baruah, D. Bodhini, V. Radha, V. Mohan, S. Banu
Cytology and Genetics.2020; 54(2): 165. CrossRef
Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus
Ahmed Mohamed Bahaaeldin, Arig Aly Seif, Amira Ibrahim Hamed, Walaa Ahmed Yousry Kabiel
Dubai Diabetes and Endocrinology Journal.2020; 26(3): 112. CrossRef
The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review
Maliheh Moradzadeh, Mohamad Reza Kalani, Amir Avan
Journal of Cellular Biochemistry.2019; 120(4): 4732. CrossRef
Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population
Kui-Chen Zhou, Hong-Wei Liu, Chen Wang, Yan-Jun Fu, Feng Jin
Medicine.2019; 98(5): e14288. CrossRef
Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
Gisela Geoghegan, Judith Simcox, Marcus M. Seldin, Timothy J. Parnell, Chris Stubben, Steven Just, Lori Begaye, Aldons J. Lusis, Claudio J. Villanueva
Molecular Metabolism.2019; 24: 44. CrossRef
Association study of the rs46522 polymorphism in UBE2Z and rs7903146 polymorphism in TCF7L2 gene with T2DM in Arab population of Khuzestan province: case-control study
Sana Shafidelpour, Ali Mohammad Foroughmand, Merhrnoosh Zakerkish, Mahdi Pourmahdi Borujeni
Medical Journal of Tabriz University of Medical Sciences and Health Services.2019; 41(6): 59. CrossRef
Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese
Sukma Oktavianthi, Made R. Saraswati, Ketut Suastika, Pande Dwipayana, Asri Sulfianti, Rahma F. Hayati, Hidayat Trimarsanto, Clarissa A. Febinia, Herawati Sudoyo, Safarina G. Malik
Molecular Biology Reports.2018; 45(5): 1135. CrossRef
Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population
Carolina Beloso, Jorge Souto, Matias Fábregat, Gerardo Romanelli, Gerardo Javiel, Adriana Mimbacas
World Journal of Diabetes.2018; 9(9): 157. CrossRef
Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy
Yan Zhuang, Fukun Niu, Defeng Liu, Juanjuan Sun, Xiaowei Zhang, Jian Zhang, Shuxia Guo
Medicine.2018; 97(40): e8388. CrossRef

Association of Estrogen Receptor α Genes PvuII and XbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran: Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian; Diabetes Metab J. 2013;37(4):270-277. Published online August 14, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.4.270

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Abstract PDF PubReader

Background

Estrogen plays a fundamental role in the pathogenesis of type 2 diabetes mellitus (T2DM). Very few studies have shown the association between estrogen receptor α (ERα), PvuII and XbaI gene polymorphisms with T2DM in both men and women. We evaluated the hypothesis that PvuII and XbaI polymorphisms of ERα gene may be associated with T2DM in adult.

Methods

From spring of 2010 to the fall of 2011, a case-control study was performed at clinical centers of Jahrom University of Medical Sciences. We included 174 patients with T2DM including men and women and 174 age, sex, and body mass index frequency-matched health controls. We analyzed the PvuII and XbaI polymorphisms of ERα by using the polymerase chain reaction-based restriction fragment length polymorphism method.

Results

No significant differences between demographic characteristics of control and patients groups were observed. Allele frequencies of both PvuII and XbaI polymorphisms were significantly different between patients and control subjects (P=0.014 vs. P=0.002, respectively). When the group was separated into women and men, logistic regression analysis of genotype distribution of PvuII (pp vs. Pp+PP) in both sexes revealed that there was no significant association of PvuII genotype with men (odds ratio [OR], 1.67; confidence interval [CI], 0.86 to 3.28; P=0.89) and women (OR, 0.96; CI, 0.53 to 1.74; P=0.12).

Conclusion

PvuII and XbaI polymorphisms in ERα are related with T2DM in the inpatient population.

Citations

Citations to this article as recorded by

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli
Human Genomics.2022;[Epub] CrossRef
Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women
Suheir Ereqat, Stéphane Cauchi, Khaled Eweidat, Muawiyah Elqadi, Abedelmajeed Nasereddin
PeerJ.2019; 7: e7164. CrossRef
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies
Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli
Journal of Diabetes Research.2015; 2015: 1. CrossRef
Genetic polymorphism of estrogen receptor alpha gene in Egyptian women with type II diabetes mellitus
Tarek M.K. Motawi, Mahmoud A. El-Rehany, Sherine M. Rizk, Maggie M. Ramzy, Doaa M. el-Roby
Meta Gene.2015; 6: 36. CrossRef

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